How to reduce vomiting after chemotherapy

About 80% of cancer patients need chemotherapy, and nausea, and vomiting are the most common gastrointestinal side effects in the chemotherapy, often in some patients difficult to accept the expected treatment, and even a fear, thus affecting the efficacy. Of chemotherapy-induced vomiting is a very complex process of pathological reflex, and the vomiting center of the medulla oblongata and the District of chemosensory stimulation by the anti-cancer drug metabolites.

In general, chemotherapy drugs, the incidence of vomiting caused by varying degrees. Vomiting rate of single-agent cisplatin, vomiting and a higher rate of cyclophosphamide, doxorubicin and other emetogenic effect is relatively weak with methotrexate, vincristine.

Select the appropriate anti-spit means necessary. First of all, should be based on age, gender, initial treatment or retreatment, individual status, patients with vomiting risk assessment, choose the means of prevention as early as possible, to help patients maintain a good mood, to avoid self-suggestion, and actively cooperate with treatment. Secondly, should be reasonable, effective use of antiemetic drugs, such as metoclopramide, dexamethasone, conventional pretreatment before chemotherapy.

In addition, the dose and mode of administration of chemotherapy drugs, emetogenic role differences. For example, in the treatment of gastric cancer, oral targeted drug capecitabine with traditional intravenous chemotherapy drug 5 - fluorouracil compared at the same time to reduce the toxicity, ease of use and prolong survival, but also can reduce vomiting. This is because, after 5 - fluorouracil administered intravenously through the blood to reach the gastric mucosa. As a prodrug of 5 - fluorouracil, capecitabine itself does not cause vomiting, absorbed into the body, under the action of the enzyme will translate into 5 - fluorouracil. Special role in targeting its concentration in the tumor cells was significantly higher than in normal gastric mucosa cells concentration, vomiting is much lighter. So, although it is administered orally, but vomiting is not serious. Meanwhile, due to be rapidly absorbed in the small intestine, Capecitabine capecitabine stay in the stomach after oral administration is very short, and simply choose the correct timing of the administration, vomiting usually will not affect the efficacy.